PDF Ebook Scaffold Hopping in Medicinal Chemistry

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Scaffold Hopping in Medicinal Chemistry

PDF Ebook Scaffold Hopping in Medicinal Chemistry

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Review

“This book outlines the key concepts, methods and examples of scaffold hopping in pharmaceutical and related industries.  Examples from academia and from industry are fully described, and this book serves as the primary reference to the current state of research in the field.”   (ChemMedChem, 1 January 2015)  

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From the Back Cover

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

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Product details

Hardcover: 328 pages

Publisher: Wiley-VCH; 1 edition (January 13, 2014)

Language: English

ISBN-10: 9783527333646

ISBN-13: 978-3527333646

ASIN: 3527333649

Product Dimensions:

7 x 0.9 x 9.8 inches

Shipping Weight: 1.8 pounds (View shipping rates and policies)

Average Customer Review:

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Amazon Best Sellers Rank:

#4,002,189 in Books (See Top 100 in Books)

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Get Free Ebook Journey Into Darkness, by John E. Douglas Mark Olshaker

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Journey Into Darkness, by John E. Douglas Mark Olshaker

Get Free Ebook Journey Into Darkness, by John E. Douglas Mark Olshaker

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About the Author

John E. Douglas is a former FBI special agent, the Bureau’s criminal profiling pioneer and one of the creators of the Crime Classification Manual. He is currently a consultant on criminal investigative analysis and the author, with Mark Olshaker, of Journey Into Darkness, The Anatomy of Motive, The Cases That Haunt Us, and Law & Disorder, among others.Mark Olshaker is a novelist, nonfiction author, and Emmy Award-winning filmmaker. He has written and produced numerous documentaries, including the Emmy-nominated PBS NOVA program Mind of a Serial Killer.

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Product details

Paperback: 400 pages

Publisher: Gallery Books (May 1, 2010)

Language: English

ISBN-10: 1439199817

ISBN-13: 978-1439199817

Product Dimensions:

5 x 1 x 8 inches

Shipping Weight: 13.6 ounces (View shipping rates and policies)

Average Customer Review:

4.3 out of 5 stars

80 customer reviews

Amazon Best Sellers Rank:

#197,600 in Books (See Top 100 in Books)

This book is big but the margins and TINY font look like they were meant for a MUCH smaller book. I have great vision but this is just too small for me. Returning and will get the hardcover.

Gives insight not only in what motivates criminals but also in the how the whole justice system works or doesn't. For example why it takes 20 plus years to carry out a death sentence.

Journey Into Darkness is written by John Douglas, one of the original criminal profilers in the Federal Bureau of Investigation. As he traveled across the country, he would drop in on killers in local prisoners and, if they were willing, would interview them in detail about the "how" and "why" and anything else they would disclose about their murders, rapes and other crimes. He had the information organized and soon began to get a real feel for "getting in the minds" of these criminals. John Douglas shares some of those stories along with the "how" & "why", as much as can be explained, in this fascinating, well-written book. There is so much to be learned, and a lot of this can be translated into how you can protect yourself against a lot of these crimes which are crimes of opportunity. Well worth the read.

For anyone interested in criminal investigation and criminal profiling this is a great read. Douglas really takes you on a journey into the FBI profiling from its very early days to current. How could it have helped in previous cases, why it was or wasn't the persecuted felons etc. He also offers parents the tools needed to empower young children who can be victims of violent and/or sexual crimes. I learned quite more than I expected and it was a very entertaining read, not dry at all!

great read, helpful advice to general public, worth every penny

For granddaughter's criminology class in college. She says it is fascinating!!

A very powerful book giving the reader insight into the realities of crime and our criminal justice system. Riveting!A.A.

Like Mindhunter, the book as well as the Netflix show, this book gives great insight into the criminals that roamed our nightmares.

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Download Ebook A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul

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A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul

Download Ebook A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul

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Review

"There’s nothing precious or pedantic about a delightful new book that celebrates Camellia sinensis, better known as the tea plant. Written by tea aficionado Sebastian Beckwith, with San Francisco author Caroline Paul, A Little Tea Book: All the Essentials From Leaf to Cup packs as much as a flavorful cup of dark, floral Himalayan black tea . . . accompanied by cheery illustrations by San Francisco artist Wendy MacNaughton." - San Francisco Chronicle"Steeped with knowledge, facts, and commentary, Sebastian's book is a wonderful read and resource for anyone who has ever enjoyed a cup of tea. He has been instrumental in guiding us through the vast world of tea over the years and this book truly shows his unrivaled passion." - Daniel Humm, James Beard Award-winning chef/co-owner of Eleven Madison Park"Like Sebastian himself, this humble book is a wealth of knowledge. Everything you ever wanted to know about tea--from leaf to label and everything in between--is planted in these pages.” - Dan Barber, James Beard Award-winning chef/co-owner of Blue Hill"Mr. Beckwith [is] an engaging, unpretentious and encyclopedic tea maven" - The New York Times" 'Pioneer,' 'iconic,' and 'amazing' were some of the words used by fellow tea freaks to describe Sebastian Beckwith . . . a foremost authority on tea." - Fast Company"Sebastian Beckwith is to tea as Julia Child was to French cooking." - Well + Good"Beckwith travels the globe to find the very best, visiting small farms in China, Taiwan, and India, among other locales." - Food Arts

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About the Author

Sebastian Beckwith is a preeminent tea authority and co-founder of In Pursuit of Tea, a purveyor of fine teas from around the world to some of the finest restaurants in the country. He divides his time between New York City and Connecticut. Caroline Paul is the New York Times bestselling author of The Gutsy Girl and Lost Cat. She lives in San Francisco. Wendy MacNaughton is the New York Times bestselling illustrator of Salt, Fat, Acid, Heat and The Gutsy Girl. She lives in San Francisco.

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Product details

Hardcover: 144 pages

Publisher: Bloomsbury Publishing (October 16, 2018)

Language: English

ISBN-10: 1632869020

ISBN-13: 978-1632869029

Product Dimensions:

5.9 x 0.7 x 7.5 inches

Shipping Weight: 12 ounces (View shipping rates and policies)

Average Customer Review:

4.9 out of 5 stars

11 customer reviews

Amazon Best Sellers Rank:

#81,442 in Books (See Top 100 in Books)

This is the kind of casually informative and beautifully illustrated book that my in-laws would keep in a guest bathroom, but hides a surprisingly intelligent discussion of high-quality tea inside. It is not a comprehensive education on tea for the near-expert (though Sebastian could probably write such a book), but instead gives a thorough overview of tea history, processing, and enjoyment. It’s neither too intimidating for the novice tea-drinker, nor too simplistic for the veteran, and it is all punctuated with beautiful photographs and watercolor illustrations to perfectly accompany the written content.

I love my oolong and I've got a large tea book library. This book packs a lot of information (some of it new to me) into its pages. It's engaging, informative, well-written and beautifully illustrated. I would absolutely recommend it to any tea lover.

Shirt and to the point

Very interesting!

A lovely little book.

I am giving it as a Christmas present to someone who drinks hot tea. It looks as if it will be perfect as such.

I love this book. Beautifully written, fun to read and educational.

Fun and interesting read

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A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul PDF

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A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul PDF

A Little Tea Book: All the Essentials from Leaf to Cup, by Sebastian Beckwith Caroline Paul PDF